چکیده (انگلیسی):

A new simple, accurate, precise, rapid and economical method was developed for the
simultaneous determination of Salmeterol xinafoate and Fluticasone propionate in their binary
mixture in bulk powder and Seritide diskus inhalation. The new method depends on new calculations
using the mixture’s absorbance at 225 and 256.5 nm where the absorptivity of Salmeterol xinafoate
is double the absorptivity of Fluticasone propionate, while the content of Salmeterol
xinafoate was determined by measuring the absolute value of the first derivative ultraviolet curves
at 352 nm, without interference from Fluticasone propionate. The proposed method was validated
and the results obtained by adopting the proposed method were statistically analyzed and compared
with those obtained by reported methods.