چکیده (انگلیسی):

The solid dispersion method was originally used to improve the dissolution properties
and the bioavailability of poorly water soluble drugs by dispersing them into water soluble carriers.
In addition to the above, dissolution retardation through solid dispersion technique using water
insoluble and water swellable polymer for the development of controlled release dosage forms
has become a field of interest in recent years. Development of controlled release solid dispersion
has a great advantage for bypassing the risk of a burst release of drug; since the structure of the
solid dispersion is monolithic where drug molecules homogeneously disperse. Despite the remarkable
potential and extensive research being conducted on controlled release solid dispersion system,
commercialization and large scale production are limited. The author expects that recent technological
advances may overcome the existing limitations and facilitate the commercial utilization of the
techniques for manufacture of controlled release solid dispersions. This article begins with an overview
of the different carriers being used for the preparation of controlled release solid dispersion
and also different techniques being used for the purpose. Kinetics of drug release from these controlled
release solid dispersions and the relevant mathematical modeling have also been reviewed in
this manuscript.