چکیده (انگلیسی):

Introduction: Compared with intravenous chemotherapy, cytoreductive surgery
(CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have been shown to improve
survival in patients with recurrent colorectal disease confined to the peritoneum. We report
our experience with CRS and HIPEC for colorectal cancer patients with peritoneal carcinomatosis,
evaluating prognostic factors for disease-free survival (DFS), overall survival (OS), and
perioperative morbidity and mortality.
Methods: All patients who underwent CRS and HIPEC were included in our study. Clinical characteristics,
operative data, and 30-day morbidity and mortality were collected and evaluated.
Results: Between January 2001 and December 2012, there were 35 consecutive patients who
underwent CRS and HIPEC at our institution. Thirty-three patients (94%) had optimal cytoreduction.
No 30-day mortality was reported, but 14 patients had postoperative complications.
The median DFS was 9.4 months (95% confidence interval 5.5e18.7 months), and DFS at 1 year,
3 years, and 5 years were 43.8%, 22.3%, and 22.3%, respectively. The median OS was calculated
to be 27.1 months (95% confidence interval 15.3e39.1), and the OS at 1 year, 3 years, and 5
years were 83.7%, 38.2%, and 19.1%, respectively. Conclusion: CRS and HIPEC can provide survival benefit, with reasonable morbidity and mortality
for Asian patients with peritoneal carcinomatosis from colorectal cancer. Patient selection
and perioperative management of the patients are key to the success of the procedure.