چکیده (انگلیسی):

The purpose of this research was to characterize and optimize
the properties of microcapsules produced by the solvent
exchange method, a new microencapsulation technique.
Reservoir-type microcapsules containing lysozyme as a
model protein were produced using a coaxial ultrasonic
atomizer under various formulation and instrument settings,
and characterized with respect to in vitro release kinetics and
stability of the encapsulated protein. The solvent exchange
method could encapsulate protein drugs with high efficiency
under an optimized condition and was mild enough to preserve
the integrity of the encapsulated lysozyme during the
process. In vitro release studies showed that the microcapsules
could release proteins in a controllable manner. The
solvent exchange method is a mild and simple microencapsulation
method that could encapsulate lysozyme, maintaining
its functional integrity.