چکیده (انگلیسی):

The protective potentials of a single exposure to 0.3 Gy of c radiation alone or with previous
treatment with certain natural products with antioxidants activity, namely curcumin (50 mg/kg,
i.p.), green tea (300 mg/kg, p.o.), garlic (100 mg/kg, p.o.) or L-carnitine (40 mg/kg, i.p.) against doxorubicin
(DOX)-induced nephropathy in rats were studied. Natural products were administered daily
for 14 successive days followed by single i.p. injection ofDOX(5 mg/kg). Rats were subjected to whole
body c radiation, 1 day before DOX administration. Serum levels of creatinine, urea, uric acid, low
density lipoprotein (LDL-C), high density lipoprotein (HDL-C) cholesterols, total proteins and albumin
as well as renal concentrations of reduced glutathione (GSH), thiobarbituric acid reactive substances
(TBARS), nitric oxide (NO) and calcium (Ca) were determined. Irradiation provided
significant protections against DOX-induced changes in all measured parameters, except renal Ca
content. All the test natural products significantly improved radiation-induced protection against
renal lipid peroxidation. L-Carnitine markedly augmented the protection toward changes in renal
GSH, NO and Ca concentrations. Curcumin increased the protection toward changes in serum albumin
and renal GSH and NO concentrations, while garlic increased the protection toward changes in
serum LDL-C level. It could be concluded that low-dose c radiation could provide prophylaxis against
DOX-induced nephropathy which might be augmented by the use of certain natural antioxidants.