چکیده (انگلیسی):

The purpose of the present study was characterization of
microparticles obtained by adsorption of poorly water soluble
drug, meloxicam, on a porous silicate carrier Florite
RE (FLR) and development of a tablet formulation using
these microparticles, with improved drug dissolution properties.
The study also reveals the use of FLR as a pharmaceutical
excipient. Meloxicam was adsorbed on the FLR
in 2 proportions (1:1 and 1:3), by fast evaporation of solvent
from drug solution containing dispersed FLR. Drug
adsorbed FLR microparticles were evaluated for surface
topography, thermal analysis, X-ray diffraction properties,
infrared spectrum, residual solvent, micromeritic properties,
drug content, solubility, and dissolution studies. Microparticles
showed bulk density in the range of 0.10 to
0.12 g/cm3. Dissolution of drug from microparticles containing
1:3, drug:FLR ratio was faster than microparticles
containing 1:1, drug:FLR ratio. These microparticles were
used for formulating directly compressible tablets. Prepared
tablets were compared with a commercial tablet. All the
prepared tablets showed acceptable mechanical properties.
Disintegration time of prepared tablets was in the range of
18 to 38 seconds, and drug dissolution was much faster in
both acidic and basic medium from prepared tablets as
compared with commercial tablet. The results suggest that
FLR provides a large surface area for drug adsorption and
also that a reduction in crystallinity of drug occurs. Increase
in surface area and reduction in drug crystallinity result in
improved drug dissolution from microparticles.