چکیده (انگلیسی):

Induction of non-specific toxicities by doxorubicin (DOX) has restricted conventional DOXbased
chemotherapy. pH-responsive dextrin nanogels (DNGs) have been fabricated in order
to incorporate and deliver DOX to specific (targeted) sites. However, adequate stability studies
of DOX-loaded DNGs are required for selection of storage conditions. The aim of this study
was therefore to evaluate the accelerated (25 °C/60% RH) and long-term (5 °C) stability of
DNGs prepared with formaldehyde (FDNGs) and glyoxal (GDNGs) as cross-linker by determining
the change in their physicochemical properties. The mean diameter decreased with
time during long-term storage. The drug content between freshly prepared (initial day) and
after storage at 5 °C for 180 days of DOX-loaded FDNGs and DOX-loaded GDNGs was not
significantly different (p > 0.05), but decreased after storage under the accelerated condition.
The release of DOX from all DNGs was pH-dependent. However, DNGs kept under the
accelerated condition showed higher amount of DOX release than those stored at 5 °C and
the freshly prepared ones. The results indicate that the stability of DNGs could be improved
by their storage at 5 °C.