چکیده (انگلیسی):

Electrospinning was used as a novel technique for fabricating polymeric nanofibers of a serum
cholesterol lowering and poorly water-soluble plant sterol, β-sitosterol. Chitosan was used
as a stabilizer/carrier polymer. The mean diameters of nanofibers ranged from 150 nm to
218 nm. β-sitosterol was in an amorphous form and homogeneously dispersed in the
nanofibers. The β-sitosterol-loaded nanofibers were freely water-soluble and exhibited very
short lag-time in releasing the plant sterol. The dissolution was associated with an immediate
recrystallization of β-sitosterol in submicron level. In conclusion, electrospinning is a
promising future technology for the formulation of poorly water-soluble plant sterols.