چکیده (انگلیسی):

The purpose of this research was to investigate novel
particulate carrier system such as solid lipid nanoparticles
(SLN) for topical application of vitamin A palmitate and to
study its beneficial effects on skin. Topical gels enriched
with SLN of vitamin Awere prepared. The solid lipid nanoparticulate
dispersion was prepared using high-pressure
homogenization technique and was incorporated into polymeric
gels of Carbopol, Pemulen, Lutrol, and Xanthan gum
for convenient application. The nanoparticulate dispersion
and its gels were evaluated for various parameters such as
particle size, in vitro drug release, in vitro penetration, in
vivo skin hydration, and skin irritation. The solid lipid nanoparticulate
dispersion showed mean particle size of 350 nm.
Differential scanning calorimetry studies revealed no drugexcipient
incompatibility. In vitro release profile of vitamin
A palmitate from nanoparticulate dispersion and its gel
showed prolonged drug release up to 24 hours, which could
be owing to embedment of drug in the solid lipid core. In
vitro penetration studies showed almost 2 times higher drug
concentration in the skin with lipid nanoparticle-enriched gel
as compared with conventional gel, thus indicating better
localization of the drug in the skin. In vivo skin hydration
studies in albino rats revealed increase in the thickness of the
stratum corneum with improved skin hydration. The developed
formulation was nonirritant to the skin with no erythema
or edema and had primary irritation index of 0.00.
Thus it can be concluded that SLN represents a promising
particulate carrier having controlled drug release, improved
skin hydration, and potential to localize the drug in the skin
with no skin irritation.