چکیده (انگلیسی):

A simple method to fabricate itraconazole (ITZ)-loaded pectin nanoparticles prepared from
nanoemulsion templates is described in this study. Nanoemulsions containing ITZ were prepared
by a mechanical homogenization using pectin as emulsifier. After freeze-drying, the
morphology, crystallinity state, thermal properties, drug dissolution and stability of the obtained
pectin nanoparticles were characterized.The results demonstrated that the morphology
of freeze-dried products was different, depending on the type of internal phase; the
nanoparticles prepared from chloroform-based nanoemulsions were completely dried and
provided a fragile characteristic. The pectin nanoparticles also demonstrated good properties
in terms of redispersibility, thermal properties, drug crystallinity and dissolution. The
ITZ-loaded pectin nanoparticles showed high percentage of drug dissolved (about 60–80%
within 2 h), and maintained their good dissolution properties even after 1-year storage. The
results suggested that freeze-dried pectin nanoparticles prepared from nanoemulsions could
be used as an effective carrier for enhancement of ITZ dissolution.