چکیده (انگلیسی):

The purpose of the study was to characterize the physico-chemical, structural, and spectral properties of the 1:1 ni-closamide and methanol, diethyl ether, dimethyl sulfoxide, N,N’ dimethylformamide, and tetrahydrofuran solvates and the 2:1 niclosamide and tetraethylene glycol hemisolvate prepared by recrystallization from these organic solvents. Structural, spectral, and thermal analysis results confirmed the presence of the solvents and differences in the structural properties of these solvates. In addition, differences in the activation energy of desolvation, batch solution calorimetry, and the aqueous solubility at 25°C, 24 hours, showed the stability of the solvates to be in the order: anhydrate > di-ethyl ether solvate > tetraethylene glycol hemisolvate > methanol solvate > dimethyl sulfoxide solvate > N,N’ di-methylformamide solvate. The intrinsic and powder dissolu-tion rates of the solvates were in the order: anhydrate > di-ethyl ether solvate > tetraethylene glycol hemisolvate > N,N’ dimethylformamide solvate > methanol solvate > di-methyl sulfoxide solvate. Although these nonaqueous sol-vates had higher solubility and dissolution rates than the monohydrous forms, they were unstable in aqueous media and rapidly transformed to one of the monohydrous forms.