چکیده (انگلیسی):

Objective: To explore the genetic diversity and the modification of antibody response in
the recent outbreak of Ebola Virus.
Methods: Sequences retrieved from public databases, the selective pressure analysis and
the homology modeling based on the all protein (nucleoprotein, VP35, VP40, soluble
glycoprotein, small soluble glycoprotein, VP30, VP24 and polymerase) were used.
Results: Structural proteins VP24, VP30, VP35 and VP40 showed relative conserved
sequences making them suitable target candidates for antiviral treatment. On the contrary,
nucleoprotein, polymerase and soluble glycoprotein have high mutation frequency.
Conclusions: Data from this study point out important aspects of Ebola virus sequence
variability that for epitope and vaccine design should be considered for appropriate targeting
of conserved protein regions.