چکیده (انگلیسی):

Basophils and mast cells play important roles in host defense against parasitic infections and allergic
responses. Several progenitor populations, either shared or specific, for basophils and/or mast cells have
been identified, thus elucidating the developmental pathways of these cells. Multiple transcription
factors essential for their development and the relationships between them have been also revealed. For
example, IRF8 induces GATA2 expression to promote the generation of both basophils and mast cells. The
STAT5-GATA2 axis induces C/EBPa and MITF expression, facilitating the differentiation into basophils and
mast cells, respectively. In addition, C/EBPa and MITF mutually suppress each other's expression. This
review provides an overview of recent advances in our understanding of how transcription factors
regulate the development of basophils and mast cells.