چکیده (انگلیسی):

Different sensitive and selective spectrophotometric methods for the determination of
ofloxacin and dexamethasone in their binary mixture were presented. Ofloxacin was determined
simply by zero order at its kmax 293.4 nm in a linear range of 1.5–12 lg mL1 with mean percentage
recovery of 100.07± 0.66% without any interference of dexamethasone even in low or high concentrations.
Dexamethasone was determined by first derivative of ratio spectra 1DD at 266.5 nm,
ratio subtraction and mean centering at 243 nm with methods in a linear range of 2.5–27.5 lg mL1
with mean percentage recoveries of 100.09± 0.70%, 100.00± 0.72% and 99.92 ± 0.62, respectively.
These methods were applied to the analysis of pharmaceutical dosage form and bulk powder
where good recoveries were obtained. The proposed methods were validated according to USP
guidelines.