چکیده (انگلیسی):

This research is devoted to create and investigate the wound healing medical materials that contain proteolytic enzymes. The aim of the study is to propose a new wound dressing design “Multiferm”TM, that is based on modified cellulose, chitosan gel and proteolytic enzymes, and represent the interaction between all of the drug components for the wound treatment such as: chitosan, modified cellulose (dialdehyde cellulose, cellulose phosphor ester) and different polyenzyme complexes (proteolytic complex from hepatopancreas of crab and bromelain). The research will also propose the scheme of the obtained materials and the components interaction mechanism. This scheme is supposed to create new materials with the special properties such as: minimal loss of biological activity during the process of dressings', obtaining, and using; minimal doze of therapeutic agent; and controlled drug release. The article and the results might be useful for everyone who is interested in cellulose chemistry, properties of proteolytic enzymes and drug development for wound healing.