چکیده (انگلیسی):

The present study was taken up to illustrate the mechanism of anti-rheumatic activity of
‘Rheumavedic capsule’, a polyherbal formulation of Vedic-bio Labs, Bangalore, in adjuvant
induced arthritic rats. Anti-inflammatory mechanism is illustrated using phlogistic agents induced
paw edema in rats. Analgesic mechanism is illustrated using Eddy’s hot plate and acetic acid
(0.6%v/v) induced writhing in mice. Histopathology of knee joint was studied.
Rheumavedic showed inhibition of inflammation mediated through Histamine, 5-Hydroxy tryptamine,
and Bradykinin. Rheumavedic showed protection in both acetic acid and Eddy’s hot plate
induced pain. Histopathology of knee joint of rat pre-treated with rheumavedic showed significant
reduction in the mononuclear infiltration, pannus formation and adhesion molecules.
The anti-rheumatic mechanism of rheumavedic is due to; inhibition of inflammatory mediators
i.e., Histamine, 5-Hydroxy tryptamine and Bradykinin., protection against prostaglandins mediated
pain, by inhibiting cyclo-oxygenase synthesis and reduction in pannus formation, by inhibiting
mononuclear infiltration.