چکیده (انگلیسی):

Background: Many patients with vocal cord dysfunction (VCD), with or without asthma, receive inappropriate
treatment because they are misdiagnosed as having difficult-to-control asthma alone. We
developed a clinical screening check list designed to aid the diagnosis of VCD.
Methods: A prospective observational study involving 80 patients aged
18 years, diagnosed with severe
asthma. After anamnesis and physical examination, physicians completed a check list with 6 questions to
identify VCD, for which the answer “yes” counted one point. Then patients underwent spirometry and
laryngoscopy. On the basis of the laryngoscopic findings, we created three patient groups: VCD (vocal
cord adduction during inspiration, n ¼ 14); unconfirmed VCD (inconclusive findings, n ¼ 29); and control
(normal findings, n ¼ 37).We attempted to determine whether any of those groups were associated with
the responses to individual questions or sets of questions on the check list.
Results: The proportion of affirmative answers to the question “Does pulmonary auscultation reveal
wheezing, predominantly in the cervical region, and/or stridor?” was significantly higher for the VCD
group than for the other two groups (P ¼ 0.006), notably in elderly patients. The variable “4 or more
affirmative answers” was more common in VCD and unconfirmed VCD groups in comparison to controls
(P ¼ 0.022).
Conclusions: A finding of wheezing or stridor on auscultation of the cervical region is suggestive of vocal
cord dysfunction, especially in elderly patients, and such dysfunction can be confirmed through laryngoscopy.
Our VCD screening check list proved to be useful in the screening of VCD among patients with
severe asthma.