چکیده (انگلیسی):

The main objective of the present work was to compare the
transdermal delivery of salbutamol sulfate (SS), a hydrophilic
drug used as a bronchodilator, from ethosomes and classic
liposomes containing different cholesterol and dicetylphosphate
concentrations. All the systems were characterized for
shape, particle size, and entrapment efficiency percentage, by
image analysis optical microscopy or transmission electron
microscopy, laser diffraction, and ultracentrifugation, respectively.
In vitro drug permeation via a synthetic semipermeable
membrane or skin from newborn mice was studied in
Franz diffusion cells. The selected systems were incorporated
into Pluronic F 127 gels and evaluated for both drug permeation
and mice skin deposition. In all systems, the presence of
spherical-shaped vesicles was predominant. The vesicle size
was significantly decreased (P G .05) by decreasing cholesterol
concentration and increasing dicetylphosphate and ethanol
concentrations. The entrapment efficiency percentage was
significantly increased (P G .05) by increasing cholesterol, dicetylphosphate,
and ethanol concentrations. In vitro permeation
studies of the prepared gels containing the selected vesicles
showed that ethosomal systems were much more efficient at
delivering SS into mice skin (in terms of quantity and depth)
than were liposomes or aqueous or hydroalcoholic solutions.