چکیده (انگلیسی):

Background:Variation in prescription of antibiotics in primary care can indicate poor clinical practice that
contributes to the increase of resistant strains. General Practitioners (GPs), as a professional group, are expected to
have a fairly homogeneous prescribing style. In this paper, we describe variation in prescribing style within and
across groups of GPs from six countries.
Methods:Cross-sectional study with the inclusion of 457 GPs and 6394 sore throat patients. We describe variation
in prescribing antibiotics for sore throat patients across six countries and assess whether variation in “prescribing
style”–understood as a subjective tendency to prescribe–has an important effect on variation in prescription of
antibiotics by using the concept of prescribing style as a latent variable in a multivariable model. We report
variation as a Median Odds Ratio (MOR) which is the transformation of the random effect variance onto an odds
ratio; Thus, MOR = 1 means similar odds or strict homogeneity between GPs’ prescribing style, while a MOR higher
than 1 denotes heterogeneity in prescribing style.
Results:In all countries some GPs always prescribed antibiotics to all their patients, while other GPs never did. After
adjusting for patient and GP characteristics, prescribing style in the group of GPs from Russia was about three times
more heterogeneous than the prescribing style in the group of GPs from Denmark–Median Odds Ratio (6.8, 95%
CI 3.1;8.8) and (2.6, 95% CI 2.2;4.4) respectively.
Conclusion:Prescribing style is an important source of variation in prescription of antibiotics within and across
countries, even after adjusting for patient and GP characteristics. Interventions aimed at influencing the prescribing
style of GPs must encompass context-specific actions at the policy-making level alongside GP-targeted interventions
to enable GPs to react more objectively to the external demands that are in place when making the decision of
prescribing antibiotics or not