چکیده (انگلیسی):

This write-up describes the comprehensive facts of tapentadol, on recent trends in synthesis,
related substances, analytical methods, pharmacodynamics, pharmacokinetics, adverse effect
and drug interaction. Chemically, tapentadol is 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl]
phenol hydrochloride. Tapentadol is a centrally-acting synthetic novel analgesic which acts as
l-opioid receptor agonist as well as norepinephrine re-uptake inhibitor. Nausea and vomiting are
common side effects and tapentadol glucuronide conjugate is a major metabolite excreted in urine.
It is synthesized by three different schemes while nine related substances were reported. Tapentadol
and its metabolites were determined in plasma matrix by chromatographic methods using spectrofluorometric
detection.