چکیده (انگلیسی):

The goal of the present study was to
evaluate the influence of the formulation and operating
conditions on pellet preparation by pan technique. To
this end, a new pelletization process, typified by the
application of powdered drug on sugar-based cores
using the GS coating system was studied. Inert cores
were intermittently treated with micronized drug
powder and adhesive solution. This treatment led to the
formation of multiple layers of drug particles around an
inert core resulting in the production of pellets that can
further be coated by different polymers to obtain
modified release formulations. Different procedures
have been used to evaluate a series of important
parameters such as initial core weight; speed of powder
application; speed, type, and position of the atomizers;
atomization degree; temperature; and air cap.
Good yield of drug layering was obtained by adjusting
the quantity of both the drug powder to apply and the
binder solution. Pellets obtained following the optimal
operating conditions (defined in a pre-formulation
study) were film coated with the acrylic polymer
Eudragit L30D in order to produce a model formulation
consisting of enteric polymer- coated pellets containing
ibuprofen. During its preparation, the formulation
showed no degradation of the drug; moreover, a low
percentage of residual humidity was obtained, indicating
that this system is very efficient for the production of
highly stable formulations. This study showed the good
performance of the GS automated pan-coating system in
obtaining enteric coated pellets prepared by powder
layering technique using aqueous solutions.