چکیده (انگلیسی):

For a drug with low bioavailability, a matrix tablet with liquid permeation enhancer
(Labrasol®) was formulated. Factorial design was used to evaluate the effect of three formulation
factors: drug percentage, polymer type (Methocel® K100M or Eudragit® L 100-55), and tablet binder
percentage (Plasdone® S-630) on tablet characteristics. Tablets were prepared by direct compression and
characterized. Compressibility index values ranged between 15.90% and 29.87% and tablet hardness
values from 7.8 to 29.78 Kp. Eudragit®-containing formulations had better compressibility index values
with higher tablet hardness. Time for 75% of drug release (T75) was calculated, and formulations
containing Eudragit® L 100-55 had faster release rates than tablet formulations with Methocel® K100M.
Formulations with Methocel® K100M fit well in the Higuchi model as indicated by their R2 values
(>0.98). Among all the formulation factors studied, polymer type displayed the highest and statistically
significant effect on compressibility index, tablet hardness, and dissolution rate. Statistical design helped
in better understanding the effect of formulation factors on tablet characteristics important for designing
formulations with desired characteristics.