چکیده (انگلیسی):

Background:Various definitions of hyperkalaemia have been used in clinical research, and data from routine
clinical practice on its incidence are sparse. We aimed to establish the incidence of hyperkalaemia in patients with
newly diagnosed heart failure in the UK general population using different definitions for the condition.
Methods:We conducted a large retrospective cohort study using data from The Health Improvement Network
primary care database. Patients with newly diagnosed heart failure (N= 19,194) were identified and followed until
the first occurrence of hyperkalaemia. Different serum potassium (K
+
) thresholds were evaluated as possible
definitions for hyperkalaemia, and incidence rates (IRs) calculated using a final operational definition both overall
and among patient sub-groups.
Results:IRs of hyperkalaemia ranged from 0.92–7.93 per 100 person-years according to the definition. Based on
considerable differences in the serum K
+
normal range used between practices, 2176 (11.3 %) individuals were
identified with a record of hyperkalaemia using our operational definition of a proportional increase of ≥10 %
above the upper bound of the normal range: IR 2.90 per 100 person-years (95 % CI 2.78–3.02) over a mean followup of 3.91 years. Incidence rates were higher in older patients, and in those with diabetes or renal impairment.
Conclusions:Hyperkalaemia is a common finding in heart failure patients in primary care, but its incidence can
vary nearly ten-fold depending on its definition. Since assessment of hyperkalaemia risk is essential for therapeutic
decision making in heart failure patients, this finding warrants consideration in future epidemiological studies.