چکیده (انگلیسی):

The present investigation aims at studying the effect of mixed surfactant system of sodium
lauryl sulphate (SLS) and alkyl polyglucosides (C10APG, C12APG and C12/14APG) on dissolution rate
enhancement of poorly water soluble drug. Aceclofenac—a non-steroidal anti-inflammatory agent was
used as a model drug as it has limited water solubility. The influence of the surfactant concentration in
various blends on dissolution rate of Solid Dispersion (SD), prepared using solution method with ethanol
as the solvent was studied and the advantage of mixed surfactant systems over the individual surfactants
was illustrated by differences in the in-vitro dissolution profiles of SD. Physico chemical evaluation
(critical micellar concentration, zeta potential and β-parameter calculations) was carried out to study the
mixed surfactant systems. Solid mixtures were characterized by Infrared spectroscopy (FT-IR); X-ray
diffraction studies (XRD) and scanning electron microscopy (SEM). It was seen that the dissolution rate
of aceclofenac from SD increased with the increase in the APG proportion relative to SLS with the
optimum ratio of 0.2 SLS:0.8 APG showing the best effect in all cases. Results obtained from physicochemical
evaluation (the decrease in the value of critical micelle concentration and higher negative value
of β-parameters) suggested the existence of synergism between surfactants blends. The observed results
in the dissolution rate enhancement could be attributed to the drug—surfactant interactions as evident
from FT-IR, SEM and XRD results.