چکیده (انگلیسی):

Objective: To evaluate the neuroprotective effects of the organic components of scallop
shells (scallop shell extract) on memory impairment and locomotor activity induced by
scopolamine or 5-methyl-10,11-dihydro-5H-dibenzo (a,d) cyclohepten-5,10-imine (MK801).
Methods: Effect of the scallop shell extract on memory impairment and locomotor activity
was investigated using the Y-maze test, the Morris water maze test, and the open
field test.
Results: Scallop shell extract significantly reduced scopolamine-induced short-term
memory impairment and partially reduced scopolamine-induced spatial memory
impairment in the Morris water maze test. Scallop shell extract suppressed scopolamineinduced
elevation of acetylcholine esterase activity in the cerebral cortex. Treatment with
scallop shell extract reversed the increase in locomotor activity induced by scopolamine.
Scallop shell extract also suppressed the increase in locomotor activity induced by
MK801.
Conclusions: Our results provide initial evidence that scallop shell extract reduces
scopolamine-induced memory impairment and suppresses MK-801-induced
hyperlocomotion.