چکیده (انگلیسی):

Objective: To study the effects of Traditional Chinese Medicine Jianpi Chushi decoction
and ointment on chronic eczema.
Methods: DNCB acetone solution was used to sensitize the skin of back and ears of 36
rats in order to establish chronic eczema model. A total of 36 rats were divided into four
groups of 9 randomly including oral medicine group, external inunctum group, combination
therapy group, and model control group respectively. Besides, the blank group of 4
healthy rats were set. The oral medicine group was given Traditional Chinese Medicine
Jianpi Chushi decoction [(Poria cocos, Chinese yam, Cortex dictamni, Zaocys dhumnade,
Rhizoma atractylodis, Pericarpium citri reticulatae, Scutellaria baicalensis, Radix
Sophorae Flavescentis, Raw Radix Paeoniae Alba, Licorice roots (Northwest Origin)] by
gastric infusion (1.6 g/mL$5 mL/d); the external inunctum group was given Qingpeng
ointment on the skin, the combination therapy group was given Jianpi Chushi decoction
by gastric infusion and Qingpeng ointment combination therapy. The model control
group was given normal saline (NS) of the same volume by gastric infusion and vaseline
on skin. Continuous administration 15 d and stopped for 3 d. The thickness difference and
weight difference of left and right ear of every group were measured and the degree of ear
swelling were evaluated. The CD4+ and CD8+ content and the IL-2, IL-4 level of serum
were detected, and the inflammatory cells counts of back skin were recorded.
Results: After treatment, the degree of ear swelling of oral medicine group, external
inunctum group and combination therapy group significant decreased compared with
model control group (P < 0.05). The CD4+, CD8+ cell content and IL-2 level of oral
medicine group, external inunctum group, combination therapy group and model control
group significant decreased compared with blank group, and IL-2 level and the inflammatory
cells count increased. After 15 d of treatment, the CD4+, CD8+ cell content and
IL-2 level of serum of oral medicine group, external inunctum group and combination
therapy group raised and the IL-4 level and the inflammatory cells count had significant
decreased compared with model control group, and the effect of combination therapy
group was more obvious (P < 0.05).
Conclusions: Qral Jianpi Chushi decoction could treat chronic eczema effectively, and
oral Chinese medicine combined with ointment could enhance and speed up the efficacy