چکیده (انگلیسی):

Objective: To evaluate the hypocholesterolemic and hypotriglyceridemic activities of
four Marrbium vulgare herb extracts using Triton WR-1339-induced hyperlipidemia in
mice.
Methods: Hyperlipidemia was developed by intraperitoneal injection of Triton (200 mg/
kg body weight). The animals were divided into main four groups of eight mice each:
normal control group, hyperlipidemic control group, hyperlipidemic plus tween-40
control and treated group. The fourth one was divided into four subgroups, petroleum
ether extract group, chloroform extract group, ethyl acetate extract group and methanol
extract treated group each of them contains two sub-sub group for treating animals with
two doses at 0.1 and 0.25 LD50.
Results: After 7 h and 24 h of treatment, the intragastric administration of all extracts
caused a significant decrease of plasma total cholesterol. Triglyceride levels were also
significantly lowered by all extracts while petroleum ether produced the lowest
decreasing level. Similar results were observed for LDL-cholesterol concentrations.
Furthermore, more polar extracts (methanol and ethyl acetate)-soluble fractions showed a
significant ameliorative action on elevated atherogenic index (AI) and LDL/HDL-C ratios,
while these atherogenic markers were not statistically suppressed by the chloroform
and petroleum ether-soluble extract.
Conclusion: The findings indicated that Marrubium may contain polar products able to
lower plasma lipid concentrations and might be beneficial in treatment of hyperlipidemia
and atherosclerosis.