چکیده (انگلیسی):

This research investigated the use of
sodium alginate for the preparation of hydrophylic
matrix tablets intended for prolonged drug release
using ketoprofen as a model drug. The matrix tablets
were prepared by direct compression using sodium
alginate, calcium gluconate, and
hydroxypropylmethylcellulose (HPMC) in different
combinations and ratios. In vitro release tests and
erosion studies of the matrix tablets were carried out in
USP phosphate buffer (pH 7.4). Matrices consisting of
sodium alginate alone or in combination with 10% and
20% of HPMC give a prolonged drug release at a fairly
constant rate. Incorporation of different ratios of
calcium gluconate leads to an enhancement of the
release rate from the matrices and to the loss of the
constant release rate of the drug. Only the matrices
containing the highest quantity of HPMC (20%)
maintained their capacity to release ketoprofen for a
prolonged time.