چکیده (انگلیسی):

Results from recent epidemiological studies strongly suggest that ingestion of food promotes immune tolerance
to food antigens, whereas exposure to food antigens through skin leads to allergic sensitization. A “dualallergen-
exposure hypothesis” has been proposed to explain those findings. However, several other recent
studies have demonstrated that some allergic diseases can be successfully treated by recurrent epicutaneous
exposure to allergens. At a glance, these two sets of findings seem to be contradictory, but we think they provide
important clues for understanding the mechanisms behind the allergy march.
Here, we propose that per-“eczema”tous sensitization drives the allergy march, and we introduce results
from several published studies in support of this hypothesis. We hope that this review may help in establishment
of new strategies for preventing the allergy march in the near future.