چکیده (انگلیسی):

Perfluorooctanoic acid (PFOA) is used in the manufacture of many industrial and commercial
products. PFOA does not readily decompose in the environment, and is biologically
persistent. Human epidemiologic and animal studies suggest that PFOA exposure elicits
adverse effects on the pancreas. While multiple animal studies have examined PFOAmediated
toxicity in the liver, little is known about the potential adverse effects of PFOA
on the pancreas. To address this, we treated C57Bl/6 mice with vehicle, or PFOA at doses
of 0.5, 2.5 or 5.0 mg/kg BW/day for 7 days. Significant accumulation of PFOA was found in
the serum, liver and pancreas of PFOA-treated animals. Histopathologic examination of the
pancreas revealed focal ductal hyperplasia in mice treated with 2.5 and 5.0 mg/kg BW/day
PFOA, while inflammation was observed only in the high dose group. Elevated serum levels
of amylase and lipase were observed in the 2.5 mg/kg BW/day PFOA treatment group.
In addition, PFOA exposure resulted in a dose-dependent increase in the level of the lipid
peroxidation product 8-iso-PGF2 and induction of the antioxidant response genes Sod1,
Sod2, Gpx2 and Nqo1. Our findings provide additional evidence that the pancreas is a target
organ for PFOA-mediated toxicity and suggest that oxidative stress may be a mechanism
through which PFOA induces histopathological changes in the pancreas.