چکیده (انگلیسی):

Background: To compare the efficacy and safety of both mechanical methods
(clips) and electrosurgical instruments, harmonic scalpel (HS) and LigaSure (LS), for securing
the cystic duct during laparoscopic cholecystectomy (LC).
Methods: During the study period from October 2010 to October 2012, 458 patients with gallbladder
stones underwent LC. A total of 38 patients were excluded from the study for different
reasons. The gallbladder was excised laparoscopically through the traditional method. The
gallbladder specimens of the patients were divided into three equal groups randomly, and
the distal part of the cystic duct was sealed ex vivo using ligaclips (Group A), HS (Group B),
and LS (Group C). The gallbladders were then connected to a pneumatic tourniquet device
and we very gradually increased the pressure with air. The bursting pressure of the cystic duct
(CDBP) was measured and differences between the three groups were calculated.
Results: The mean CDBP was 329.7
38.8 mmHg in the ligaclip group, 358.0
33.1 mmHg in
the HS group, and 219.7
41.2 mmHg in the LS group. A comparison of the mean CDBP between
the groups indicated the superiority of HS over ligaclip and LS. CDBP was significantly
higher in the ligaclips group compared with the LS group (p <0.001). HS and ligaclips were
found to be safe sealers as their mean CDBP was found to be higher (>195 mmHg) than the
maximum common bile duct pressure, whereas for LS the CDBP range was 150e297 mmHg,
indicating that it is not safe for sealing.
Conclusion: HS is a safe alternative to clips. In fact, it was even safer than clips. By contrast,
LS is not safe for cystic duct sealing.