چکیده (انگلیسی):

Objectives: To assess whether the cutaneous features in patients with dengue fever are
associated with abnormal blood biochemistry, complications, and poor disease outcome.
Methods: Forty five patients with dengue fever were identified at a medical center in
Kaohsiung, Taiwan, from September to November 2014. All cases were exclusively
caused by type 1 dengue virus. Patients were classified into two groups, based on the
presence or absence of skin rash, and their rash was subclassified into maculopapular,
morbilliform, and petechial types. Clinical symptoms, laboratory data, disease outcome,
and complications were compared between the two groups.
Results: Thirty two patients with dengue fever developed skin rash (SP group, n = 32)
while the rest of 13 did not (SN group, n = 13). The patient numbers in the maculopapular,
morbilliform, and petechial group were 4, 21, and 7, respectively. The SP
group was younger (P = 0.001), experienced more pruritus (P = 0.008) and more swollen
palms/soles (P = 0.015) than the SN group. However, the SN group had greater genital
mucosa involvement (P = 0.008), higher platelet transfusion rate (P = 0.003), and lower
hemoglobin and hematocrit levels (P = 0.030) than the SP group. Patients with morbilliform
lesions had a higher incidence of palm/sole swelling, less genital mucosal
involvement, and a lower platelet transfusion rate than did patients with maculopapular or
petechial lesions.
Conclusions: Cutaneous manifestations provide an important clue to dengue fever. In
patients with dengue fever, those with skin rash tend to have itching and swelling of the
palms/soles, however, those without skin rash tend to have more complications and poor
disease outcomes.