چکیده (انگلیسی):

Background: Studies show that immunoglobulin E (IgE) is produced in the local nasal mucosa in allergic
rhinitis patients. However, no study involved the measurement of IgE levels in the local nasal mucosal
tissue in allergic rhinitis patients. This study aimed to measure the local IgE levels in the nasal mucosal
tissue and to compare the levels of total IgE and specific IgEs in the serum and the inferior turbinate nasal
mucosa in allergic rhinitis patients using the AlaSTAT 3gAllergy assay (Siemens Healthcare Diagnostics
AG, Erlangen, Germany).
Methods: Total IgE antibodies and allergen-specific IgE antibodies in each sample of nasal mucosal tissue
from 11 allergic rhinitis patients were measured with the AlaSTAT 3gAllergy assay. We compared the
levels of total IgE and IgEs specific for house dust (HD), mites, and cedar pollen in the serum and the
inferior turbinate.
Results: The total IgE levels and the cedar pollen-specific IgE levels in the inferior turbinate mucosal
tissue correlated significantly with their respective levels in serum. The HD- and mite-specific IgE levels
in the inferior turbinate mucosal tissue did not correlate significantly with their respective levels in the
serum.
Conclusions: Our results evaluating the correlations between nasal mucosal and serum levels of antigenspecific
IgE indicate that IgE produced in the nasal mucosa affects the IgE levels in the serum, especially
the cedar pollen-specific IgE.
Copyright © 2016, Japanese Society of Allergology.