چکیده (انگلیسی):

Tuberculosis is the leading cause of death in adults from a single infectious agent, killing
about 3 million people every year. One-third of the human population is thought to be
infected by the causative agent Mycobacterium tuberculosis. Multidrug resistance isolates are
one of the most important concerns in tuberculosis control. In this study, we used MIRUVNTR
to determine MDR-TB transmission in Tabriz. A hundred and twenty M. tuberculosis
isolates were collected from patients who referred to TB center of Tabriz and characterized
for drug resistance and typing by MIRU-VNTR method. Thirty percent of the isolates were
resistant to at least one drug. Among Iranian isolates only two isolates (1.9%) were MDR
and in patients from the Republic of Azerbaijan four isolates (28.6%) were MDR. By MIRUVNTR
typing eighty eight distinct profiles were identified, including 20 clustered profiles
and 68 unique patterns and fifty two isolates (43.3%) included in clusters. The minimum
estimate of the proportion of tuberculosis transmission in East Azerbaijan with MIRUVNTR
was 26.7% and 14% of MDR isolates acquired infections recently. Results of the
present study showed that high percent of TB cases are sensitive to antibiotics. MIRUVNTR
typing showed a limited number of MDR-TB transmission in our isolates set.
Because of the increasing number of patients referred from Rep. of Azerbaijan with MDRTB,
we need more stewardship and controlling programs for these patients for preventing
the outbreak of MDR-TB in our region.