چکیده (انگلیسی):

Feasibility of developing a transdermal drug delivery of
fluoxetine has been investigated. Permeation studies of
fluoxetine across human cadaver skin were carried out
using Franz diffusion cells. The receptor phase consisted
of pH 7.4 phosphate buffer maintained at 37
C. Permeation
enhancement of fluoxetine, either in the salt or base form,
was achieved using various enhancers like azone, SR-38,
and ethanol. Various O/W microemulsion systems of
fluoxetine were developed to study their effect on the skin
permeation of fluoxetine. The results indicated that ethanol
at 65% vol/vol was able to increase the permeation of
fluoxetine the most, while microemulsion systems showed
decrease in the permeation of fluoxetine. The permeation
of fluoxetine obtained using a 65% vol/vol ethanolic solution
was found to be sufficient to deliver the required dose
(20—80 mg) from a patch of feasible size. The results seem
promising for developing a transdermal drug delivery system
of fluoxetine.