چکیده (انگلیسی):

Objective/background: Thalassemia is a monogenic hematologic disease that has the highest
prevalence globally. In addition, there is complexity of the genetic background associated with
a variety of phenotypes presented among patients. Genetic heterogeneity related to fetal
hemoglobin (HbF) production has been reported as an influencing phenotypic factor of
b-thalassemia (b-thal). Therefore, this study aimed to find the effect of these genetic modifiers,
especially in the XmnI locus, rs11886868, rs766432 (BCL11A), and rs9399137 (HBS1LMYB),
among b-thal and HbE/b-thal patients in Indonesia, according to laboratory and clinical
http://dx.doi.org/10.1016/j.hemonc.2016.02.003
1658-3876/
2016 King Faisal Specialist Hospital & Research Centre. Published by Elsevier Ltd.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
* Corresponding author at: Department of Molecular Biology, Faculty of Medicine, Jenderal Soedirman University, Jalan Medika Gumbreg
Number 1, Purwokerto 53146, Central Java, Indonesia.