چکیده (انگلیسی):

The aim of this review is to provide a broad perspective on intestinal absorption and the
impact of intestinal first-pass metabolism on both clearance and drug–drug interaction prediction
along with its historical perspectives. The review also considers abilities to bridge the gap between
the increasing amount of intestinal in vitro data and the importance of intestinal first-pass metabolism
in vivo. The significance of efflux transporters on the intestinal absorption is also discussed.