چکیده (انگلیسی):

This study investigated whether Raman and Near Infrared (NIR) spectroscopy could predict
tablet properties. Granules were produced on a continuous line by varying granulation parameters.
Tableting process parameters were adjusted to obtain uniform tablet weight and
thickness. Spectra were collected offline and tablet properties determined with traditional
analyzing methods. Partial Least Squares (PLS) regression was used to correlate spectral information
to tablet properties, but predictive models couldn’t be established. Principal
component analysis (PCA) was effectively used to distinguish theophylline concentrations
and hydration levels and multiple linear regression (MLR) analysis allowed insight on how
granulation parameters affect granule and tablet properties.