چکیده (انگلیسی):

The objective of the present work was to carry out a systematic evaluation of flow of
pharmaceutical powders and granules using compendial and non-compendial methods. Angle of repose,
bulk density, tapped density, Carr’s compressibility index, and Hausner ratios were evaluated.
Additionally, flow was characterized using a powder rheometer in which a sensitive force transducer
monitors the forces generated as a result of the sample displacement. The critical attributes such as
cohesivity index, caking strength, and flow stability were determined for samples. The samples consisted
of different grades of magnesium stearate powder including bovine, vegetable, and food grade, physical
mixture powder blend consisting of a model formulation, granules prepared by various methods including
slugging, high shear granulator, and fluid bed dryer. Lubricant efficiency was also determined for
granules lubricated with various concentrations of magnesium stearate. It was observed that the
compendial methods were often non-discriminating for minor variations in powder flow. The additional
characterization such as cohesivity, and caking strength were helpful in understanding the flow
characteristics of pharmaceutical systems. The flow stability test determined that the powders were not
affected by the test conditions on the rheometer. The non-compendial tests were discriminating to even
minor variations in powder flow.