چکیده (انگلیسی):

In this study, the acute and subchronic toxicity effect of the Syzygium aqueum leaf extract
(SA) was evaluated. For the acute toxicity study, a single dose of 2000 mg/kg of the SA was
given by oral-gavage to male Sprague-Dawley (SD) rats. The rats were observed for mortality
and toxicity signs for 14 days. In the subchronic toxicity study the SA was administered
orally at doses of 50, 100, and 200 mg/kg per day for 28 days to male SD rats. The animals
were sacrificed at the end of the experiment. The parameters measured including food and
water intake, body weight, absolute and relative organ weight, blood biochemical tests and
histopathology observation. In both the acute and subchronic toxicity studies, SA did not
show any visible signs of toxicity. There were also no significant differences between the
control and SA treated rats in terms of their food and water intake, body weight, absolute
and relative organ weight, biochemical parameters or gross and microscopic appearance
of the organs. There were no acute or subchronic toxicity observed and our results indicate
that this extract could be devoid of any toxic risk. This is the first in vivo study reported the
safety and toxicity of SA.