چکیده (انگلیسی):

Objective: To evaluate the supportive effects of Rosa damascene (R. damascene)
essential oil on epididymal sperm quality and histopathology of testes following long
term administration of copper sulfate in mice.
Materials and methods: The study comprised of four different groups of six mice as
follows: group Cu, which received 0.1 mL copper sulfate solution at dose of 100 mg/kg,
group R which received 0.1 mL R. damascene essential oil at dose of 1 mg/kg, treatment
group (T) which received copper sulfate solution (100 mg/kg) and treated by
R. damascene essential oil (1 mg/kg), and control group (C) which received the same
volume of normal saline. The supplements were gavaged in all animals every other day,
during experimental period. All animals of each experimental group were sacrificed 42
days after the beginning of experiment.
Results: Results showed that sperm concentration, motility and viability in group Cu
were significantly decreased after 6 weeks, and severe degenerative changes were
observed in testicular tissues in comparison with the control group. In treatment group,
significant improve in the sperm count, motility and viability, and normal architecture in
most seminiferous tubules with organized epithelium was observed compared to the
group Cu.
Conclusions: Administration of the essential oil of R. damascene owning to its antioxidant
properties is able to protect the testis and epididymal sperm from the adverse
effects of copper poisoning in mice.