چکیده (انگلیسی):

Aim: To investigate the effect of preoperative Lugol's iodine on intraoperative bleeding in patients with
hyperthyroidism.
Material and methods: This controlled, randomized, prospective cohort was carried out on 40 patients
who admitted for surgery due to hyperthyroidism. Cases were randomly assigned to receive either
preoperative treatment with Lugol solution (Group 1) or no preoperative treatment with Lugol solution
(Group 2). Group 3 (n ¼ 10) consisted of healthy adults with no known history and signs of hyperthyroidism.
Blood flow through the thyroid arteries of patients was measured by color flow Doppler
ultrasonography. Free T3, free T4, TSH, thyroid volume and the resistance index of the four main thyroid
arteries were measured in all patients.
Results: There was not a significant difference between gender, preoperative serum thyroid hormone
levels, or thyroid gland volumes between groups 1 and 2. The mean blood flow of the patients in Group 1
was significantly lower than values in Group 2. When age, gender, thyroid hormone, TSH, thyroid volume,
blood flow, and Lugol solution treatment were included as independent variables, Lugol solution
treatment (OR, 7.40; 95% CI, 1.02e58.46; p ¼ 0.001) was found to be the only significant independent
determinant of intraoperative blood loss. Lugol solution treatment resulted in a 7.40-fold decrease in the
rate of intraoperative blood loss.
Conclusion: Preoperative Lugol solution treatment was found to be a significant independent determinant
of intraoperative blood loss. Moreover, preoperative Lugol solution treatment decreased the rate of
blood flow, and intraoperative blood loss during thyroidectomy