چکیده (انگلیسی):

The objective of this study was to evaluate Kollidon SR for the development of extended
release Albuterol Sulphate matrix tablets in comparison with other polymers as Hydroxypropylmethylcellulose
K15M, Carbopol 71G NF, and Eudragit L100-55. The mechanical properties of the
tablets were improved as concentration of Kollidon SR or other polymers increased. It was found
that Kollidon SR 30% (w/w) and HPMC 30% (w/w) tablets have f2 similarity factor of 83.5 in their
Albuterol Sulphate dissolution profile. The marketed product was found to release 99.7% of drug
content within 8 h, while Kollidon SR and HPMC tablets with 30% (w/w) polymer concentration
level released 92.7% and 92.9% respectively of drug content within 8 h. Kollidon SR has a unique
character of maintaining tablets geometric shape until the end of dissolution test, this is mainly due
to the water insoluble content, polyvinyl acetate, forming 80% (w/w) of Kollidon SR, while the
remaining content 20% (w/w) is the water soluble, polyvinylpyrrolidone, responsible for pore formation
causing a diffusion controlled release. Drug release from all previous formulations is best
described to be controlled by more than one kinetic mechanism of release.
In conclusion, Kollidon SR and HPMC and Carbopol were found to be potential candidates for
the development of extended release of Albuterol Sulphate tablets.