چکیده (انگلیسی):

The purpose of this study was to investigate the influence of the supercritical CO2 processing
on the particle size and morphology of puerarin crystals.The process parameters included
solvents, temperature, pressures, antisolvent times, addition volumes, antisolvent addition
rates and solute concentrations. After being processed, the dramatic reduction of the
dimensions and the change of the crystal shape were noticed. Decreasing the antisolvent
addition rate, increasing the temperature and the addition volume below 50 ml led to a decrease
in size.The new crystal of puerarin generated at the optimal conditions was 30.34 μm.
The solvent of methanol and the concentration of 60 mg/ml were found to determine the
type and degree of crystallinity of particles. These results showed that this process has the
potential to produce a drug recrystallization product with newly generated crystal forms
and the size of drug particles could be controlled through the tuning of various experimental
conditions.