چکیده (انگلیسی):

The purpose of this study was to
investigate the effect of 2 additives, poly(ethylene
glycol) (PEG) 1000 and 1,2,3-tridecanoyl glycerol
(tricaprin), on the physico-chemical characteristics and
in vitro release of a model protein, bovine serum
albumin (BSA), form poly(D,L-lactic-co-glycolic acid)
(PLGA) microspheres. BSA-loaded microspheres were
prepared by the double emulsion solvent evaporation
method. Additives were incorporated into microspheres
to modify the release of protein. The addition of PEG
1000 and tricaprin changed the surface characteristics
of microspheres from smooth and nonporous to porous
and dimpled, respectively. The in vitro release profiles
showed that the additives significantly (P < 0.05)
increased the early-stage release of BSA from
microspheres.