چکیده (انگلیسی):

Objective: To analyze the effects of Labisia pumila (L. pumila) extract on the markers of
oxidative stress in ovariectomized rats.
Methods: Twenty-five female Wistar rats were divided into five treatment groups
(n = 5): the control group, the ovariectomized group, the ovariectomized group treated
with L. pumila extract of various doses (10 mg/kg, 20 mg/kg, and 40 mg/kg). L. pumila
extract was administered daily for 8 weeks.
Results: The levels of malondialdehyde and superoxide dismutase (SOD) were subjected
to spectrophotometric analysis. Serum levels of malondialdehyde and SOD were
significantly higher in the group of rat model of post-menopausal osteoporosis than that
of the control group (P < 0.05). All doses of L. pumila administered significantly
decreased the serum levels of malondialdehyde relative to the group of rat model of postmenopausal
osteoporosis, reaching the levels comparable to those of the control group
(P < 0.05). The second dose of L. pumila significantly decreased the levels of SOD
relative to those of the group of rat model of post-menopausal osteoporosis, although it
did not reach the levels of SOD of the control group (P < 0.05).
Conclusion: The ethanol extract of L. pumila normalizes lipid peroxidation in the rat
model of post-menopausal osteoporosis via the mechanism of endogenous antioxidant
replacement.