چکیده (انگلیسی):

The polymer, a-cellulose, is a fibrous residue obtained by
delignification of wood pulp1 or more recently from agricultural
wastes such as groundnut shells, rice husks, and
maize cobs.2-4 a-Cellulose differs from b- and g-cellulose
by being insoluble in 17.5% wt/vol sodium hydroxide
solution. It is a fluffy powder with a bulk density of
0.36 g/cm—3, true particle density of 1.59 g/cm—3, and porosity
0.77.4 It is a poorly flowing powder with angle of repose
up to 45
C.2 Nevertheless, it exhibits plastic compression5
and may therefore be explored as a direct compression base,
thus displaying similar property as low crystallinity celluloses6
and the well-known microcrystalline cellulose. It
hydrates readily, absorbing up to 4.5% of its own weight of
water.2 This aqueous swelling property is its major asset as
a disintegrant in tablet formulations. Thus, the disintegrant
property of a-cellulose sourced from agricultural wastes
such as groundnut shells, rice husks, and maize cobs has
been investigated in previous studies.2-4 The outcome was
that a-cellulose is an effective disintegrant in various tablet
formulations. However, accelerated stability studies7 suggested
that moisture uptake would have the potential to
impair the disintegrant property of a-cellulose in tablet formulations.
Paracetamol tablets were used in that study and
gelling of the a-cellulose powder was proposed as the possible
mechanism for the humidity effect.