چکیده (انگلیسی):

Myocardial infarction (MI) continues to be a major public health problem in the world.
Statins exhibit cardio-protective effects by several mechanisms beyond their lipid lowering activity.
Quercetin is a natural flavonoid that possesses significant anti-oxidant and antiinflammatory activities.
The present study aimed to investigate the effects of pretreatment with atorvastatin (10 mg/kg)
and quercetin (50 mg/kg), as well as their combination on isoprenaline-induced MI in rats. Markers
chosen to assess cardiac damage included serum activity of creatine kinase-MB (CK-MB) and
serum level of cardiac troponin-I (cTn-I), as well as oxidative stress and inflammatory biomarkers
including serum levels of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-a), and interleukin-
10 (IL-10) as well as cardiac contents of lipid peroxides, reduced glutathione (GSH), and
nitrite. Furthermore, ECG monitoring and histological examinations of cardiac tissues were done.
Isoprenaline increased serum CK-MB activity and cTn-I level as well as inflammatory and oxidative
stress biomarkers. In addition, it produced ST-segment elevation and degenerative changes in heart
tissues. Pretreatment with atorvastatin suppressed significantly the elevated levels of cTn-I, CRP,
TNF-a, and IL-10 in serum coupled with reduction in cardiac lipid peroxides; however, it increased
cardiac nitrite content. Quercetin decreased isoprenaline-induced changes in oxidative stress and
inflammatory biomarkers with marked improvement in ECG and histopathologic alterations. Combination
of quercetin with atorvastatin resulted in similar protective effects. In conclusion, quercetin
can be regarded as a promising cardio-protective natural agent in MI alone or combined with atorvastatin.