چکیده (انگلیسی):

Background: Gastroesophageal reflux disease (GERD) is one of the most common causes of chronic cough
and often coexists with asthma or chronic obstructive pulmonary disease (COPD); however, it is unknown
whether there are differences in the effect of GERD on these diseases. The purpose of this study
was to assess the difference in the effect of GERD on cough-related quality of life and disease status in
asthma and COPD in a real-world setting.
Methods: Subjects were 132 patients with overall controlled asthma and 102 patients with stable COPD.
They completed the frequency scale for symptoms of GERD (FSSG), a validated Japanese questionnaire for
GERD, the Leicester Cough Questionnaire (LCQ), and the Asthma Control Test (ACT) or COPD assessment
test (CAT) questionnaires.
Results: We found that 29 (22.0%) patients with asthma and 22 (21.6%) patients with COPD had GERD.
There was no difference in the FSSG scale between the diseases. The patients with GERD, regardless of
having asthma or COPD, had lower LCQ scores affecting all health domains and lower ACT or higher CAT
scores than those without GERD. Overall, the patients with COPD had lower LCQ scores regardless of the
presence or absence of GERD. The FSSG scale was negatively correlated with the LCQ total score in
asthma and in COPD. In contrast, the FSSG scale was positively correlated with the CAT score but not with
the ACT score.
Conclusions: Patients with GERD had impaired cough-related quality of life, poor asthma control or more
symptoms and impacts of COPD.