چکیده (انگلیسی):

In present study two formulations of Koflet (syrup and lozenges) were evaluated against
pyridine-induced pharyngitis in rats. Topical application of 10% pyridine showed extravasation
of Evans blue stain as a characteristic feature of on-going inflammation. In addition,
the levels of TNF- (p < 0.01) and IL-6 (p < 0.01) were significantly increased compared to
control. Further, histopathology of the pharyngeal tissue showed submucosal gland hypertrophy,
severe mucosal inflammation characterized by presence of mononuclear cells and
neutrophils along with haemorrhages and congestion; however, saline applied animals
(normal control) showed normal cytoarchitecture of the pharynx. Interestingly, pretreatment
with dexamethasone (1 mg/kg, p.o.), Koflet lozenges (KL) (500 and 1000 mg/kg,
p.o.) and Koflet syrup (KS) (2 and 4 ml/kg, p.o.) for 7 days showed significant and dose
dependent protection by decreasing the EB dye extravasation, and serum levels of TNF-
and IL-6. In addition, histopathological findings have further supported the protective effect
of Koflet formulations. These findings suggest that, both Koflet syrup and Koflet lozenges
are highly effective in treating non-infectious type of pharyngitis. Among the two formulations
KS was found to be more potent than KL, and possible mechanism of action thought to
be mediating through inhibition of TNF- and/or phospholipids–arachidonic acid pathway.